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and Russell, M.H. PowerPoint Presentation to USEPA. Environ. Studies of peroxisome proliferation and tumour development in these cells in mice (which are more sensitive to peroxisome proliferation than rats) would potentially provide more useful information for the MOA analysis. and Fletcher, T. (2013). Tinten und Toner (PC18), Produkte zur Behandlung von Papier und Pappe (PC26), Textilfarben,-appreturen und -imprägniermittel (PC 34) 2.2.1 Materialuntergruppen. Taniyasu et al. and Clewell, H.J., 3rd. No standard deviation or confidence interval was provided by authors. The HBV for the non-cancer assessment, which was 0.0002 mg/L for hepatocellular hypertrophy in rats, is more conservative than the HBV for Leydig cell tumours of 0.03 mg/L. Griffith, F. D. and Long, J. E. (1980). Partitioning and removal of perfluorooctanoate during rain events: the importance of physical-chemical properties. The clean-up procedures involved a washing step after the sample enrichment on the SPE cartridge and a filtration to remove solids from the final extract (Yamashita et al., 2004; Larsen and Kaiser, 2007; van Leeuwen and Boer, 2007). and Fenton, S.E. Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy. Environ. Manche Fluorpolymere sehen aus wie Gummi (siehe Kunststoffe). Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008. Method (ETS-8-154.3) was developed and validated by 3M for PFOA analysis in drinking water, groundwater and surface water samples. Hori, H., Yamamoto, A., Hayakawa, E., Einaga, H., Taniyasu, S., Yamashita, N. and Kutsuna, S. (2005). The only study indicating changes in thyroid hormone levels reported decreased free and total T3 and T4 in monkeys exposed for 6 months (Butenhoff et al., 2002). (*4) Quelle: Strukturformeln aus den Anhang XV Dossiers der ECHA. Polyfluoroalkyl chemicals in the serum and milk of breastfeeding women. Env. (2012). Physikalische Gefahren: Kann gegenüber Metallen korrosiv sein. World Health Organization, Geneva, Switzerland. Les composés perfluorés dans les cours d'eau et l'eau potable du Québec méridional. Martin, M.T., Brennan, R.J., Hu, W., Ayanoglu, E., Lau, C., Ren, H., Wood, C.R., Corton, J.C., Kavlock, R.J. and Dix, D.J. C8 probable link reports (probable link evaluations for autoimmune disease, infectious disease, neurodevelopmental disorders in children, respiratory disease, stroke, and thyroid disease). Furdui, V., Crozier, P., Reiner, E. and Mabury, S. (2008). [cited in OECD (2008)]. and Olsen, J. (2001). A species difference in the peroxisome proliferator-activated receptor alpha-dependent response to the developmental effects of perfluorooctanoic acid. [cited in Kato (2011)]. Technol., 39: 2383-2388. [cited in Fromme (2007); Butt (2010)]. Disposition of perfluorooctanoic acid in the rat after single and subchronic administration. Sci.., 138(1): 76-88. Similar experiments conducted in ovariectomized siblings of the exposed offspring (ovariectomy performed at PND 21/22) indicated no effect on body weight and abdominal fat weight, but an increased relative weight of interscapular brown fat at 1 mg/kg bw per day (no effect at 5 mg/kg bw per day). Increases in liver weight were also observed in mice exposed in utero or peripubertally to PFOA; descriptions of these results can be found in Section 9.2.5.4. Carcinog. With sufficiently validated models, this approach is considered to be the most robust approach for performing animal-to-human extrapolations. Although increased liver weight and hepatocellular hypertrophy can sometimes be considered effects that are adaptive rather than adverse in their own right, evidence of other histological effects in the liver at higher concentrations provide an indication of their progression upon continued exposure (ECETOC, 2002; Hall et al., 2012). The only study including more than one dose identified a LOAEL of 1.3 mg/kg bw per day (no NOAEL) in male rats for liver toxicity (3M, 1983; Sibinski, 1987; Butenhoff et al., 2012b). The Canadian Health Measures Survey (CHMS), Cycle 1 (2007-2009) indicates that PFOA plasma levels in adult males (geometric mean [GM]: 2.94 ng/mL; 95% CI: 2.74-3.15, 95th percentile: 5.98 ng/mL, n=1376) are higher than in adult females (GM: 2.17 ng/mL; 95% CI: 1.99-2.36, 95th percentile: 4.99 ng/ml, n=1504) (Health Canada, 2010).

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